摘要

抗生素抗性基因（ARGs）的环境行为和迁移模式吸引了相当多的研究兴趣。然而，关于相应和非相应污染物对沿海环境中ARGs命运的影响的研究很少。在本研究中，在相应和不相应污染物的背景下，分析了莱州湾水体和沉积物样品中intI1，sul1，sul2，qnrS和aac（6'） - Ib的分布。 intI1，sul1和sul2基因的丰度从内河口到沿海地区呈现出明显的下降趋势。沉积物中sul1 / sul2和磺胺类抗生素残留物之间以及intI1和sul1 / sul2之间存在强烈的正相关关系。统计分析表明，非相应的污染物与ARG丰度部分相关。这些结果表明，非相应的污染物可能对莱州湾ARGs和intI1的丰度有直接或间接的影响。

The environmental behaviors and migration patterns of antibiotic resistance genes (ARGs) have attracted considerable research interest. However, there has been little research concerning the effects of corresponding and non-corresponding contaminants on the fate of ARGs in coastal environments. In the present study, the distribution of intI1, sul1, sul2, qnrS and aac(6')-Ib were analyzed in water and sediment samples of Laizhou Bay in the context of corresponding and non-corresponding contaminants. The abundance of intI1, sul1 and sul2 genes exhibited a clear decreasing trend extending from the inner estuary to the coastal area. Strong and positive correlations existed between sul1/sul2 and sulfonamide antibiotic residues in sediments, and between the abundances of intI1 and sul1/sul2. Statistical analyses indicated that non-corresponding contaminants were partially correlated with ARG abundances. These results suggest that non-corresponding contaminants may have direct or indirect influences on the abundances of ARGs and intI1 in the Laizhou Bay.

https://www.ncbi.nlm.nih.gov/pubmed/29571399