摘要

OXA-427是比利时一家医院在肠杆菌科不同物种中遇到的一种新的D类碳青霉烯酶。 为了研究这种基因的扩散，我们描述了两种含有从肺炎克雷伯氏菌和阴沟肠杆菌复合株分离的blaOXA-427基因的质粒的比较分析。 含有blaOXA-427的两个IncA / C2质粒共享相同的骨架，然而，在肺炎克雷伯菌中，该质粒被共同整合到IncFIB质粒中，形成具有多个多抗区的321kb大质粒。

OXA-427 is a new class-D carbapenemase encountered in different species ofEnterobacteriaceae in a Belgian hospital. To study the dispersal of this gene, we describe the comparative analysis of two plasmids containing the blaOXA-427 gene isolated from a Klebsiella pneumoniae and an Enterobacter cloacae complex strain. The two IncA/C2 plasmids containing blaOXA-427 share the same backbone, however, in the K. pneumoniae this plasmid is cointegrated into an IncFIB plasmid forming a 321 kb megaplasmid with multiple multi-resistance regions.

http://aac.asm.org/content/early/2018/01/04/AAC.01448-17.abstract