摘要
      抗生素的过度使用和不当处置在全球范围内引发了严重的公共卫生风险。具体而言，人类和动物体内抗生素代谢不完全，导致抗生素大量释放到自然生态系统中，并导致携带抗生素耐药基因的抗生素耐药细菌增殖。此外，用于厌氧消化的有机原料通常富含残余抗生素和抗生素抗性基因。因此，了解它们在厌氧消化过程中的命运已成为近年来的一个重要研究热点。先前的研究表明，在厌氧消化过程中，各种工艺参数可以显著影响抗生素抗性基因的繁殖，并通过土地施用消化物传播。本文综述了厌氧消化过程中工艺参数对抗生素抗性基因繁殖的影响及其影响背后的内在基础。在文献综述的基础上，总结了关键的研究差距和挑战，以指导未来的研究前景。
Abstract
The overuse and inappropriate disposal of antibiotics raised severe public health risks worldwide. Specifically, the incomplete antibiotics metabolism in human and animal bodies contributes to the significant release of antibiotics into the natural ecosystems and the proliferation of antibiotic-resistant bacteria carrying antibiotic-resistant genes. Moreover, the organic feedstocks used for anaerobic digestion are often highly-rich in residual antibiotics and antibiotic-resistant genes. Hence, understanding their fate during anaerobic digestion has become a significant research focus recently. Previous studies demonstrated that various process parameters could considerably influence the propagation of the antibiotic-resistant genes during anaerobic digestion and their transmission via land application of digestate. This review article scrutinizes the influences of process parameters on antibiotic-resistant genes propagation in anaerobic digestion and the inherent fundamentals behind their effects. Based on the literature review, critical research gaps and challenges are summarized to guide the prospects for future studies.

https://www.sciencedirect.com/science/article/abs/pii/S0960852422005181