摘要
      卤代抗生素，如氟苯尼考（FLO）的生产和消费量仍然很高，同时伴有大量含抗生素的废水，这将导致抗生素抗性基因（ARGs）在传统生物系统中的潜在增殖和传播。本研究表明，在紫外线照射过程中，通过添加亚硫酸盐引入还原性物种（主要是Hradical dot），加速了FLO的分解速度，从单一紫外线光解系统中的0.1379 min−1增加到紫外线/亚硫酸盐系统中的0.3375 min−1。UV/亚硫酸盐体系中光分解的增强归因于脱卤性能的提高和苯环位置磺甲基的额外去除，这是FLO抗菌活性的代表性结构。与单次UV光解相比，UV/亚硫酸盐高级还原工艺为floR的进化抑制节省了40%的光能需求，并且其在后续生物处理系统中的相应类别的ARGs被控制在阴性组的水平。与UV/H2O2和UV/过硫酸盐系统相比，FLO在UV/S系统中的分解速率最高，并保留了共存有机化合物的相应碳源，以在随后的生物处理过程中潜在地利用微生物代谢。这些结果表明，UV/亚硫酸盐高级还原工艺可以作为一种很有前途的预处理选择，用于在随后的生物处理过程中预防卤代抗生素的代表性ARGs增殖。
Abstract
The production and consumption of halogenated antibiotics, such as florfenicol (FLO), remain high, accompanied by a large amount of antibiotic-containing wastewater, which would induce the potential proliferation and transmission of antibiotic resistance genes (ARGs) in conventional biological systems. This study revealed that the introduction of reductive species (mainly Hradical dot) by adding sulfite during UV irradiation process accelerated the decomposition rate of FLO, increasing from 0.1379 min−1 in the single UV photolytic system to 0.3375 min−1 in the UV/sulfite system. The enhanced photodecomposition in UV/sulfite system was attributed to the improved dehalogenation performance and additional removal of sulfomethyl group at the site of the benzene ring, which were the representative structures consisting of FLO antibacterial activity. Compared with single UV photolysis, UV/sulfite advanced reduction process saved the light energy requirement by 40 % for the evolutionary suppression of floR, and its corresponding class of ARGs in subsequent biotreatment system was controlled at the level of the negative group. Compared with UV/H2O2 and UV/persulfate systems, the decomposition rate of FLO in the UV/S system was the highest and preserved the corresponding carbon source of the coexisting organic compounds for the potential utilization of microbial metabolism in subsequent biotreatment process. These results demonstrated that UV/sulfite advanced reduction process could be adopted as a promising pretreatment option for the source prevention of representative ARGs proliferation of halogenated antibiotics in subsequent biotreatment process.

https://www.sciencedirect.com/science/article/abs/pii/S0048969722049439