摘要
      为了保护水资源，本研究分析了紫外线、超声波和微波增强过硫酸盐活化氧化产生的磺胺嘧啶降解中间体的生态毒性和抗生素抗性基因（ARGs）诱导能力。分析了由电子转移和单线态氧（1O2）的贡献差异以及不同降解产物的生态毒性变化引起的五种降解途径。微观实验表明，实际水体中的微生物群落随着SDZ和降解中间体的变化而发生显著变化，其中优势属为气单胞菌属、Cupriavidus属、伊丽莎白金氏菌属和无色杆菌属。除了对细菌的选择性压力外，降解中间体对磺酰胺ARGs（sul4、sul1和sul2）也比SDZ产生一定程度甚至更强的诱导作用。此外，通过网络分析揭示了磺酰胺ARGs的潜在宿主。这些结果提供了对抗生素降解机制和ARGs发生的更好理解，这有助于控制ARGs的传播。
Abstract
To preserve the water resources, this study has analyzed the ecotoxicity and antibiotic resistance genes (ARGs) induction capacity of sulfadiazine degradation intermediates resulting from persulfate activation oxidation enhanced by ultraviolet, ultrasound and microwave. The five degradation pathways caused by the contribution discrepancy of electron transfer and singlet oxygen (1O2) and variations in the ecotoxicity of different degradation products were analyzed. Microcosm experiment exhibited that the microbial community in actual water changed significantly with SDZ and degradation intermediates, in which the dominant genera were Aeromonas, Cupriavidus, Elizabethkingia and Achromobacter. Except for the selective pressure on bacteria, the degradation intermediates also exert a certain degree or even stronger induction on sulfonamide ARGs (sul4, sul1 and sul2) than SDZ. Furthermore, the potential hosts for sulfonamide ARGs were revealed by network analysis. These results provide a better understanding of antibiotics degradation mechanism and ARGs occurrence, which is useful for controlling the spread of ARGs.

https://www.sciencedirect.com/science/article/abs/pii/S096085242201639X