摘要

低收入和中等收入国家（LMIC）滥用抗生素促使抗生素耐药性的发展，并可能在全球传播。 已经提出了特定于LMIC的策略，该策略试图减少人类滥用抗生素但同时改善抗生素使用。 然而，迄今为止的大多数方法都没有考虑动物和环境水库对抗生素耐药性的影响越来越大，这可能会加剧中低收入国家抗生素耐药性危机。 特别是，目前的策略并未优先考虑增加抗生素用于陆地食物 - 动物和水产养殖生产的影响，食品安全不足和广泛的环境污染。 在这里，我们提出了解决新兴“一健康”挑战的新方法。

Antibiotic misuse in lower- and middle-income countries (LMICs) contributes to the development of antibiotic resistance that can disseminate globally. Strategies specific to LMICs that seek to reduce antibiotic misuse by humans, but simultaneously improve antibiotic access, have been proposed. However, most approaches to date have not considered the growing impact of animal and environmental reservoirs of antibiotic resistance, which threaten to exacerbate the antibiotic resistance crisis in LMICs. In particular, current strategies do not prioritize the impacts of increased antibiotic use for terrestrial food-animal and aquaculture production, inadequate food safety, and widespread environmental pollution. Here, we propose new approaches that address emerging, One Health challenges.

https://academic.oup.com/cid/article-abstract/66/6/963/4810441?redirectedFrom=fulltext