摘要
      在这项工作中，从西班牙阿尔巴塞特大学医院综合楼获得的数据被选为案例研究，以进行消毒实验。为了做到这一点，测试了不同配置的电化学反应器对复杂尿液的消毒。结果显示，在180分钟（0.423 Ah dm−3）后，当使用微流体流通反应器工作时，每种测试的细菌都能达到4-6 log的细菌去除率。MIKROZON®细胞在60分钟后达到完全消毒（1.212 Ah dm−3），导致SEM图像中观察到的细胞壁严重损伤。电生成消毒剂在溶液中的浓度分布可以解释观察到的差异。此外，使用MIKROZON®细胞，ARGs浓度的平均下降顺序如下：blaKPC（4.18-log）>blaTEM（3.96-log）>ermB（3.23-log）。这种电臭氧发生器可以被认为是降低抗生素耐药性传播风险的合适替代品。因此，这项研究深入了解了用于消毒复杂医院尿液基质的不同电化学反应器，并有助于通过消除ARGs来减少抗生素耐药性的传播。这是一个当今非常重要的课题，需要进一步研究。
Abstract
In this work, data obtained from the University Hospital Complex of Albacete (Spain) were selected as a case study to carry out the disinfection experiments. To do this, different configurations of electrochemical reactors were tested for the disinfection of complex urines. Results showed that 4–6 logs bacterial removal were achieved for every bacterium tested when working with a microfluidic flow-through reactor after 180 min (0.423 Ah dm−3). The MIKROZON® cell reached a total disinfection after 60 min (1.212 Ah dm−3), causing severe damages induced in the cell walls observed in SEM images. The concentration profiles of the electrogenerated disinfectants in solution could explain the differences observed. Additionally, a mean decrease in the ARGs concentration ranked as follows: blaKPC (4.18-logs) > blaTEM (3.96-logs) > ermB (3.23-logs) using the MIKROZON® cell. This electro-ozonizer could be considered as a suitable alternative to reduce the risk of antibiotic resistance spread. Hence, this study provides an insight into different electrochemical reactors for the disinfection of complex hospital urine matrices and contributes to reduce the spread of antibiotic resistance through the elimination of ARGs. A topic of great importance nowadays that needs to be further studied.

https://www.sciencedirect.com/science/article/abs/pii/S0304389421029976