摘要
      抗生素的广泛使用导致了抗生素耐药性基因（ARGs）在水生环境中的出现。作为一种新兴的环境污染物，其对水环境的污染引起了人们的广泛关注。然而，到目前为止，饮用水分配系统中抗生素残留和抗生素耐药性基因的报道很少。在这里，我们研究了氯抗性细菌的氯抗性机制和抗生素抗性机制之间的相关性和协调性。抗生素诱导耐氯细菌（CRB）对NaClO产生耐药性，因此低剂量消毒剂不能使CRB失活。我们提出了一种策略，通过控制水网络前段可生物降解溶解有机碳（BDOC）的浓度来控制CRB的生长。此外，我们在混合培养后筛选了两株具有不同抗生素耐药性的耐氯细菌，结果表明，抗生素耐药性可以在不同种类的细菌之间水平传播。然后，非致病菌可以被用作载体，导致病原体对抗生素产生耐药性，最终对人类健康造成危害。通常，水处理厂中添加的抗生素、抗生素抗性基因和氯消毒剂会与供水管网中的细菌相互作用，从而对饮用水造成污染。
Abstract
The extensive use of antibiotics leads to the occurrences of antibiotic resistance genes (ARGs) in aquatic environment. As an emerging environmental pollutant, its pollution in aquatic environment has aroused widespread concern. However, the residues of antibiotics and antibiotic resistance genes in drinking water distribution system were barely reported up to now. Here, we studied the correlation and coordination between chlorine resistance mechanism and antibiotic resistance mechanism of chlorine-resistant bacteria. Antibiotics induce the resistance of chlorine-resistant bacteria (CRB) to NaClO, so that low-dose disinfectants can not inactivate CRB. We put forward a strategy to control the growth of CRB by controlling the concentration of biodegradable dissolved organic carbon (BDOC) in the front section of the water network. Moreover, We screened two strains of chlorine-resistant bacteria with different antibiotic resistance after mixed culture, the results showed that antibiotic resistance could spread horizontally among different kinds of bacteria. Then, the non-pathogenic bacteria can be used as a carrier, causing the pathogen to become resistant to antibiotic, and ultimately pose harm to human health. Generally, the antibiotic, antibiotic resistant genes, and the chlorine disinfectants added in water treatment plants will interact with bacteria in the water supply pipe network, which causes pollution to drinking water.

https://www.sciencedirect.com/science/article/abs/pii/S0013935122003723