摘要
      抗生素耐药性基因（ARGs）被认为是一种新出现的污染物。本研究旨在调查胶州湾ARGs的空间和介质分布模式，以及这些模式背后的原因。结果表明，氨基糖苷类和MLSB抗性基因在所有样本中占主导地位，沿海水域、海湾水域和沉积物中ARGs的相对丰度分别为10−6至10−2、10−6到10−3和10−5至10−2-拷贝/16S rRNA。ARGs的显著空间变化解释为沿海水域更容易受到人类活动的影响，而环境物理化学因素在海湾水域中起着至关重要的作用。介质分布变化的内在原因是两种介质中不同的组装过程，而外部原因是水中和沉积物中的ARGs分别主要受环境物理化学因素和重金属的影响。
Abstract
Antibiotic resistance genes (ARGs) are considered a newly emerging contaminant. This study aimed to investigate the spatial and media distribution patterns of ARGs in Jiaozhou Bay, as well as the reasons behind these patterns. The results revealed that aminoglycoside and MLSB resistant genes predominated in all samples, and the relative abundance of ARGs ranging from 10−6 to 10−2, 10−6 to 10−3 and 10−5 to 10−2 copies/16S rRNA in coastal water, bay water, and sediments, respectively. The significant spatial variation of ARGs was explained by the fact that the coastal water was more susceptible to human activities, whereas environmental physicochemical factors played a crucial role in the bay water. The intrinsic reason for the media distribution variation was the different assembly processes in the two media, while the external reason was that the ARGs in the water and sediments were mainly influenced by environmental physicochemical factors and heavy metals, respectively.

https://www.sciencedirect.com/science/article/abs/pii/S0025326X22011729