摘要
      作为一种新兴的环境污染物，抗生素耐药性的广泛存在引发了一系列环境问题和人类健康问题。农业实践诱导的大量抗生素残留对土壤-植物系统中的细菌群落施加了选择性压力，这通过水平基因转移促进了抗生素抗性基因（ARGs）的发生和传播。因此，在粮食摄入的影响下，收获时作物中ARGs的富集可能会引起公众健康的严重关切。在这篇综述中，强调了抗生素耐药性在土壤-植物系统中的流行和传播。此外，还总结和讨论了ARGs在土壤环境和植物区室之间转移的不同潜在机制和检测方法。另一方面，还提出并讨论了抗生素耐药性在土壤-植物系统中转移和分布的各种影响因素。针对抗生素残留和耐药性的暴露，总结了相应的危害识别评估，这可以为普通人群的毒理学耐受性提供有益的指导。最后，还提出了检测和管理ARGs传播的进一步研究重点。
Abstract
As an emerging environmental contaminant, the widespread of antibiotic resistance has caused a series of environmental issues and human health concerns. A load of antibiotic residues induced by agricultural practices have exerted selective pressure to bacterial communities in the soil-plant system, which facilitated the occurrence and dissemination of antibiotic resistance genes (ARGs) through horizontal gene transfer. As a result, the enrichment of ARGs within crops at harvest under the influence of food ingestion could lead to critical concerns of public health. In this review, the prevalence and dissemination of antibiotic resistance in the soil-plant system are highlighted. Moreover, different underlying mechanisms and detection methods for ARGs transfer between the soil environment and plant compartments are summarized and discussed. On the other hand, a wide range of influencing factors for the transfer and distribution of antibiotic resistance within the soil-plant system are also presented and discussed. In response to exposure of antibiotic residues and resistomes, corresponding hazard identification assessments have been summarized, which could provide beneficial guides of the toxicological tolerance for the general population. Finally, further research priorities for detection and management ARGs spread are also suggested.

https://www.sciencedirect.com/science/article/abs/pii/S0048969723004709