摘要
      随着越来越多的环境污染物的出现，抗生素和抗生素耐药性基因（ARGs）导致环境中的抗生素耐药性（AMR）大幅增加。群体感应（QS）是一种细菌细胞间的通信过程，它调节许多性状和基因表达，包括ARGs和有助于AMR发展的相关基因。在此，我们总结了细菌QS在环境中AMR发展中的作用、生理学和遗传机制。首先，介绍了QS对AMR的影响。接下来，系统分析了QS在促进AMR发展的细菌生理行为中的作用，包括膜渗透性、策略性运动、生物膜形成、持久性形成和小菌落变异（SCVs）。此外，还讨论了QS对ARGs表达的调节、影响ARGs形成的活性氧（ROS）的产生以及加速ARGs传播的水平基因转移（HGT），以揭示AMR发展的分子机制。这篇综述为更好地理解AMR的演变和对AMR预防的新见解提供了参考。
Abstract
As more environmental contaminants emerging, antibiotics and antibiotic resistance genes (ARGs) have caused a substantial increase of antimicrobial resistance (AMR) in environment. Quorum sensing (QS) is a bacterial cell-to-cell communication process that regulates many traits and gene expression, including ARGs and the related genes that contribute to AMR development. Herein, we summarize the role, physiology, and genetic mechanisms of bacterial QS in AMR development in the environment. First, the effect of QS on AMR is introduced. Next, the role of QS in bacterial physiological behaviors that promote AMR development, including membrane permeability, tactic movement, biofilm formation, persister formation, and small colony variants (SCVs), is systematically analyzed. Furthermore, the regulation of QS on the expression of ARGs, generation of reactive oxygen species (ROS), which affects ARGs formation, and horizontal gene transfer (HGT), which accelerates the transmission of ARGs, are discussed to reveal the molecular mechanism for AMR development. This review provides a reference for a better understanding of AMR evolution and novel insights into AMR prevention.

https://www.sciencedirect.com/science/article/abs/pii/S0269749123002403