摘要

      染色质调节基因的破坏与许多神经认知综合征有关。虽然这些基因中的大多数在各种细胞类型中普遍表达，但许多染色质调节因子作用于在突触发育和可塑性中发挥核心作用的活性调节基因（ARGs）。最近的文献表明，神经元中ARG表达的破坏与在各种神经认知综合征中观察到的人类表型之间存在联系。染色质生物学的进展已经证明了染色质结构，从核小体占据到拓扑相关结构域等高级结构，是如何影响转录动力学的。这篇综述讨论了这些不同水平的染色质结构的动力学及其对ARGs表达的影响。The disruption of chromatin-regulating genes is associated with many neurocognitive syndromes. While most of these genes are ubiquitously expressed across various cell-types, many chromatin regulators act upon activity regulated genes (ARGs) that play central roles in synaptic development and plasticity. Recent literature suggests a link between ARG expression disruption in neurons with the human phenotypes observed in various neurocognitive syndromes. Advances in chromatin biology have demonstrated how chromatin structure, from nucleosome occupancy to higher-order structures such as topologically associated domains, impacts the kinetics of transcription. This review discusses the dynamics of these various levels of chromatin structure and their influence on the expression of ARGs.

https://portlandpress.com/biochemsoctrans/article-abstract/51/2/703/232770/Modulation-of-chromatin-architecture-influences