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三功能铜网/Cu2O@FeO纳米阵列用于抗生素的高效降解、抗生素耐药性细菌的灭活和抗生素耐药性基因的损伤

发布者:抗性基因网 时间:2023-06-09 浏览量:440

摘要
      三功能铜网/Cu2O@FeO纳米阵列异质结构是通过集成来设计和制造的Cu2O@FeO通过原位生长和相变过程在Cu网格(CM)上形成纳米阵列。它被成功地应用于有效缓解抗生素污染,包括抗生素的降解、抗生素耐药菌(ARB)的灭活和抗生素耐药基因(ARGs)的损伤。在可见光照射下,CM/Cu2O@FeO纳米阵列对抗生素表现出优异的降解效率(例如,在25种抗生素中高达99% 对于盐酸四环素,TC为min),这是由于产生的活性氧(ROS),特别是占优势的·O2−。它可以完全灭活大肠杆菌。 大肠杆菌(HB101),初始数量约为108 菌落总数 毫升−十分之一 min,这主要归因于1D纳米结构、溶解的金属离子和产生的ROS的协同作用。同时,它能够在180后破坏ARG 光降解的最小值,包括分别为3.3 log10的tetA(vs TC)、3.4 log10的aphA(vs硫酸卡那霉素,KAN)和4.4 log10的tnpA(vs氨苄青霉素,AMP)。这项工作探索了一种在可见光下处理抗生素污染的绿色方法。
Abstract
Trifunctional Cu-mesh/Cu2O@FeO nanoarrays heterostructure is designed and fabricated by integrating Cu2O@FeO nanoarrays onto Cu-mesh (CM) via an in situ growth and phase transformation process. It is successfully applied to efficiently mitigate the antibiotic pollution, including degradation of antibiotics, inactivation of antibiotic-resistant bacteria (ARB), and damage of antibiotics resistance genes (ARGs). Under visible-light irradiation, CM/Cu2O@FeO nanoarrays exhibit a superior degradation efficiency on antibiotics (e.g., up to 99% in 25 min for tetracycline hydrochloride, TC), due to the generated reactive oxygen species (ROS), especially the dominant ·O2−. It can fully inactivate E. coli (HB101) with initial number of ~108 CFU mL−1 in 10 min, which is mainly attributed to the synergistic effects of 1D nanostructure, dissolved metal ions, and generated ROS. Meanwhile, it is able to damage ARGs after 180 min of photodegradation, including tetA (vs TC) of 3.3 log10, aphA (vs kanamycin sulfate, KAN) of 3.4 log10, and tnpA (vs ampicillin, AMP) of 4.4 log10, respectively. This work explores a green way for treating antibiotic pollution under visible light.

https://onlinelibrary.wiley.com/doi/full/10.1002/eem2.12299