摘要

细菌素是由多种细菌产生的蛋白质抗菌化合物，其已成功用作：（i）食品生物防腐剂; （ii）抗生物膜剂; 和（iii）目前现有抗生素的添加剂或替代品，以尽量减少耐药菌株出现的风险。 然而，目前的挑战是细菌素作为生物防腐剂/抗菌剂的使用存在几个限制。 克服这些限制的最有前景的途径之一是使用纳米制剂。 本综述突出了使用细菌素控制病原微生物的实际困难，并概述了纳米技术在改善抗微生物活性和这些肽的物理化学性质中的作用。

Bacteriocins are proteinaceous antibacterial compounds, produced by diverse bacteria, which have been successfully used as: (i) food biopreservative; (ii) anti-biofilm agents; and (iii) additives or alternatives to the currently existing antibiotics, to minimize the risk of emergence of resistant strains. However, there are several limitations that challenge the use of bacteriocins as biopreservatives/antibacterial agents. One of the most promising avenues to overcome these limitations is the use of nanoformulations. This review highlights the practical difficulties with using bacteriocins to control pathogenic microorganisms, and provides an overview on the role of nanotechnology in improving the antimicrobial activity and the physicochemical properties of these peptides.

https://www.frontiersin.org/articles/10.3389/fmicb.2016.01385/full