摘要

近年来抗生素耐药性急剧增加，但抗生素药物管道停滞不前。因此需要新的治疗方法来继续治疗抗生素耐药性感染。目前正在探索的一种潜在策略是使用非抗生素化合物来增强当前使用的抗生素的活性。包括精油（EO）在内的许多天然产品具有广谱的抗菌活性，因此已经为此进行了调查。本文旨在回顾最近关于EO的抗菌活性及其与抗生素相互作用的文献，考虑EO和抗生素作为抗生素抗性的潜在解决方案的双重作用机制。已经报道了EO及其组分与抗生素之间的协同相互作用，包括抗生素在敏感分离菌中重新敏化的一些情况，以支持该策略以控制抗生素抗性。然而，方法和解释标准缺乏一致性使得研究组合的功效难以得出结论。除了初步鉴定抗菌相互作用之外，协同效应往往不被探索，尽管有许多假设和未来研究的建议，但作用机制很少被定义。在能够进一步发展成新的抗菌制剂之前，需要做大量的工作来充分了解EO-抗生素联合。

Antibiotic resistance has increased dramatically in recent years, yet the antibiotic pipeline has stalled. New therapies are therefore needed to continue treating antibiotic resistant infections. One potential strategy currently being explored is the use of non-antibiotic compounds to potentiate the activity of currently employed antibiotics. Many natural products including Essential Oils (EOs) possess broad spectrum antibacterial activity and so have been investigated for this purpose. This article aims to review recent literature concerning the antibacterial activity of EOs and their interactions with antibiotics, with consideration of dual mechanisms of action of EOs and antibiotics as a potential solution to antibiotic resistance. Synergistic interactions between EOs and their components with antibiotics have been reported, including several instances of antibiotic resensitization in resistant isolates, in support of this strategy to control antibiotic resistance. However, a lack of consistency in methods and interpretation criteria makes drawing conclusions of efficacy of studied combinations difficult. Synergistic effects are often not explored beyond preliminary identification of antibacterial interactions and mechanism of action is rarely defined, despite many hypotheses and recommendations for future study. Much work is needed to fully understand EO-antibiotic associations before they can be further developed into novel antibacterial formulations.
 
https://www.tandfonline.com/doi/abs/10.1080/1040841X.2018.1423616